Print Papillary thyroid cancer, BRAF mutation positive Founded more than 40 years ago, Genentech is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious and life-threatening medical conditions. IL22-Fc The majority of men will die of mCRPC, with a median life expectancy of less than three years.
Solid tumors Solid tumors Tocilizumab Cobimetinib Personalized Cancer Vaccine DLK is a neuronally-enriched kinase that is designed to mediate stress-induced cell death.Managed by Genentech Research and Early Development.Prasinezumab (RG7935) is a monoclonal antibody targeting alpha-synuclein, a protein that may misfold and be involved in the pathogenesis of Parkinson's disease (PD).This molecule is being developed in collaboration with Prothena.RG7816 (GABA-Aa5 PAM) is a small molecule positive allosteric modulator of the GABAA α5 receptor, which is expressed in key brain regions for autism spectrum disorder (ASD).Semorinemab (RG6100), an anti-tau monoclonal antibody that targets extracellular tau in the brain, is being evaluated for the potential treatment of Alzheimer’s disease (AD).Managed by Genentech Research and Early Development.This molecule is being developed in collaboration with AC Immune SA.Tenecteplase (RG-3625) is a tissue plasminogen activator (tPA) that binds fibrin and converts plasminogen to plasmin.
A Phase II trial evaluating anti-PDL1 in patients with metastatic non-small cell lung cancer is planned. Refractory indolent Non Hodgkin's lymphoma Systemic lupus erythematosus
It binds to two integrins, alpha4beta7 and alphaEbeta7. Lebrikizumab
Crenezumab
Interstitial lung disease Baloxavir marboxil Receptor tyrosine kinase signaling, Akt pan-inhibitor. Chronic lymphocytic leukemia and non-Hodgkin's lymphoma A phase I clinical trial is evaluating ipatasertib with rucaparib (a small-molecule PARP inhibitor) for the treatment of metastatic … Amyotrophic lateral sclerosis The BRAF protein is a key component of the RAS-RAF pathway involved in normal cell growth and survival.
Sustained delivery age-related macular degeneration It is specifically approved to treat non-metastatic castration-resistant prostate cancer (nmCRPC) in conjunction with surgical or medical castration.The medication is taken by mouth twice per day with food. Vismodegib For Actemra full prescribing information, including Boxed WARNINGS, Medication Guide and additional important safety information, please visit Brain shuttle gantenerumab (RG6102) technology is designed to transfer gantenerumab across the blood brain barrier and increase antibody concentrations in the brain.Crenezumab (Anti-Abeta, MABT5102A, RG7412) is a humanized monoclonal antibody, which binds to amyloid beta (Abeta). Solid tumors Polycythemia vera Tiragolumab
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